| Date | Opponent / Event | Location | Time / Result |
| 11/05/12 | vs. Bellarmine | Lexington, Ky. | W, 113-33 |
| 11/10/12 | vs. Delaware State | Lexington, Ky. | 1:00 p.m. ET |
| 11/13/12 | at Baylor | Waco, Tx. | 6:00 p.m. ET |
| 11/17/12 | vs. High Point | Lexington, Ky. | 1:00 p.m. ET |
| 11/23/12 | vs. Morehead State | Lexington, Ky. | 4:00 p.m. ET |
| 11/25/12 | vs. USC Upstate | Lexington, Ky. | 1:00 p.m. ET |
| 11/28/12 | vs. Miami (Oh) | Lexington, Ky. | 11:00 a.m. ET |
| 12/02/12 | at Louisville | Louisville, Ky. | 2:00 p.m. ET |
| 12/07/12 | vs. DePaul | Lexington, Ky. | 7:00 p.m. ET |
| 12/09/12 | vs. Middle Tenn. St. | Lexington, Ky. | 1:00 p.m. ET |
| 12/18/12 | at Pepperdine | Malibu, Ca. | 10:00 p.m. ET |
| 12/21/12 | at UC Santa Barbara | Santa Barbara, Ca. | 6:00 p.m. ET |
| 12/28/12 | vs. Alcorn State | Lexington, Ky. | 7:00 p.m. ET |
| 12/30/12 | vs. Marist | Lexington, Ky. | 1:00 p.m. ET |
| 01/03/13 | vs. Florida | Lexington, Ky. | 7:00 p.m. ET |
| 01/06/13 | at Alabama | Tuscaloosa, Al. | 3:00 p.m. ET |
| 01/10/13 | vs. Texas A&M | Lexington, Ky. | 6:00 p.m. ET |
| 01/13/13 | at Missouri | Columbia, Mo. | 1:30 p.m. ET |
| 01/17/13 | vs. Mississippi State | Lexington, Ky. | 7:00 p.m. ET |
| 01/20/13 | vs. Auburn | Lexington, Ky. | 2:00 p.m. ET |
| 01/24/13 | at South Carolina | Columbia, S.C. | 7:00 p.m. ET |
| 01/27/13 | vs. LSU | Lexington, Ky. | 3:00 p.m. ET |
| 02/03/13 | vs. Georgia | Lexington, Ky. | 2:00 p.m. ET |
| 02/07/13 | at Arkansas | Fayetteville, Ak. | 8:00 p.m. ET |
| 02/10/13 | at Vanderbilt | Nashville, Tn. | 4:00 p.m. ET |
| 02/14/13 | vs. South Carolina | Lexington, Ky. | 7:00 p.m. ET |
| 02/18/13 | at Texas A&M | College Station, Texas | 7:00 p.m. ET |
| 02/24/13 | at LSU | Baton Rouge, La. | 3:00 p.m. ET |
| 02/28/13 | at Ole Miss | Oxford, Ms. | 8:00 p.m. ET |
| 03/03/13 | vs. Tennessee | Lexington, Ky. | 3:30 p.m. ET |
